Proton MRS in Kennedy disease: Absolute metabolite and macromolecular concentrations

Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS.

The regional distribution of brain metabolites was studied in several cortical white and gray matter areas, cerebellum, and thalamus of young adults with use of quantitative single-voxel proton MRS at 2.0 T. Whereas the neuronal compound N-acetylaspartate is distributed homogeneously throughout the brain, N-acetylaspartylglutamate increases caudally and exhibits higher concentrations in white m...

Occipital Proton Magnetic Resonance Spectroscopy (1H-MRS) Reveals Normal Metabolite Concentrations in Retinal Visual Field Defects

BACKGROUND Progressive visual field defects, such as age-related macular degeneration and glaucoma, prevent normal stimulation of visual cortex. We investigated whether in the case of visual field defects, concentrations of metabolites such as N-acetylaspartate (NAA), a marker for degenerative processes, are reduced in the occipital brain region. METHODOLOGY/PRINCIPAL FINDINGS Participants kn...

Localized proton MRS of the human hippocampus: metabolite concentrations and relaxation times.

Absolute concentrations and proton relaxation times of major metabolites in the human hippocampus were determined with use of fully relaxed, short-echo time STEAM localization sequences at 2.0 T (20 normal adults). Mean metabolite concentrations were 7.6+/-0.9 mM for total Nacetylaspartate (tNAA), 6.9+/-0.8 mM for total creatine (tCr), 2.1+/-0.3 mM for choline-containing compounds (Cho), and 6....

Proton(1H) Magnetic Resonance Spectroscopy: Absolute metabolite concentrations in normal aging human brain at 3Tesla

Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations.

BACKGROUND Results from cerebral proton (1)H-MR spectroscopy studies of neonates with perinatal hypoxic-ischemic injury have generally been presented as metabolite peak-area ratios, which are T1- and T2-weighted, rather than absolute metabolite concentrations. We hypothesized that compared with (1)H-MR spectroscopy peak-area ratios, calculation of absolute metabolite concentrations and relaxati...